Many easy things may cause your afterburner software to cease functioning in games or just not start. You may solve your issues by just upgrading the app or using other simple fixes that I will provide. I can tell you that the software problems are simple to fix. These issues can arise during normal use or when playing games.
However, there are a number of issues that may arise in the program that can become a problem for you. One of the most popular applications for GPU overclocking and customization is MSI Afterburner.